LYCOS RETRIEVER 
Zyprexa: Symptoms
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Case study analysis indicates that more than ten percent of all Zyprexa overdose cases have included the following symptoms: agitation or aggression, rapid heart beat, slurred speech, and decreased consciousness ranging from sedation to coma. Less common consequences of Zyprexa overdose can include more serious complications such as: aspiration, cardiac-pulmonary arrest, heart arrhythmia, delirium, neuroleptic malignant syndrome, respiratory arrest or depression, convulsions, seizures, and high or low blood pressure.
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Zyprexa may increase the effects of medicines that are used to control high blood pressure. This could lead to very low blood pressure, dizziness, and fainting. Zyprexa may ... increase the effects of drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives, pain relievers, anxiety medicines, muscle relaxants, and any other drug that makes you feel sleepy or relaxed. Zyprexa may decrease the effects of drugs used to treat Parkinson's disease which could lead to worsening Parkinson’s symptoms.
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As with all antipsychotic medications, a rare and potentially fatal condition known as NMS has been reported with Zyprexa. If signs and symptoms appear, immediate discontinuation is recommended. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia). Additional signs may include elevated creatinine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure.
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The answer to Donna's problem was to be treated with Zyprexa, starting at a 5 mg. daily dose, roughly equivalent to 3 mgs. of Risperdal. "If her symptoms persist after one week, it is important to increase the dose to 10 mg--and you can feel comfortable doing so with Zyprexa's safety profile."
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Unaware of these adverse effects, physicians felt free to prescribe Zyprexa® for a wide variety of symptoms - from anxiety to simple headaches. Many feel that as a direct result of this policy, Lilly was able to rack up additional billions of dollars in sales.
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