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Zyprexa: Schizophrenia
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Lilly's best-selling drug is Zyprexa, a schizophrenia medicine that has come under scrutiny for serious side effects, including obesity and diabetes, in long-term users. It ... makes insulins like Humulin and Humalog and sells the diabetes drug Byetta with Amylin Pharmaceuticals Inc.
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"We remain confident in the safety and efficacy of Zyprexa based on the depth and breadth of scientific research conducted around the world. Zyprexa is a lifesaving drug and it has helped millions of people worldwide with schizophrenia and bipolar disorder regain control of their lives."
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[A]nother example of an anti-psychotic drug allegedly presenting links to diabetes and weight gain is Zyprexa, manufactured by Eli Lilly & Co. and prescribed for the treatment of schizophrenia and bipolar mania. [MORE: ZYPREXA OFF-LABEL]
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"We have had eight patients out of possibly thirty-five patients on Zyprexa show up with high blood sugars," Marrero's letter states. "Two patients had to be hospitalized due to out of control diabetes....We have certainly never seen this with Haldol, Navane, Risperdal and others to this extent." It is not clear whether the patients were being treated for schizophrenia or bipolar disorder.
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The most common treatment-emergent adverse event associated with Zyprexa in placebo-controlled, short-term schizophrenia and bipolar mania trials was somnolence. Other common events were dizziness, weight gain, personality disorder (COSTART term for nonaggressive objectionable behavior), constipation, akathisia, postural hypotension, dry mouth, asthenia, dyspepsia, increased appetite and tremor.
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