LYCOS RETRIEVER 
Zoloft: Antidepressants
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The antidepressant effect of Zoloft is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. Zoloft has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, Zoloft blocks the uptake of serotonin into human platelets. In receptor binding studies, Zoloft has no significant affinity for adrenergic (alpha(1), alpha(2) and beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5-HT1A, 5-HT1B, 5-HT2) or benzodiazepine binding sites.
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A: In July 2006, the FDA issued two alerts related to Zoloft. The first FDA alert announced the results of a study concerning the use of antidepressant medicines during pregnancy by mothers of babies born with a serious condition called persistent pulmonary hypertension of the newborn (PPHN). Click here for more information on this FDA alert.
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Switching from other antidepressants or antiobsessional agents - There is limited controlled experience regarding the optimal timing of switching from other antidepressants or antiobsessional agents to Zoloft. Care and prudent medical judgement should be exercised when switching, particularly from long-acting agents such as fluoxetine. The duration of washout period which should intervene before switching from one selective serotonin reuptake inhibitor (SSRI) to another has not been established.
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The study, which appears in the Oct. 27 issue of the Journal of the American Medical Association, found that cognitive-behavior therapy was more effective at relieving the symptoms of obsessive-compulsive disorder than treatment solely with the antidepressant sertraline (Zoloft). However, the study ... found a combination of the two was the most effective of all.
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The natural antidepressant Deprex is a safe and effective depression treatment scientifically formulated to elevate mood without the potentially harmful side effects commonly associated with Zoloft. Self-help techniques, psychotherapy, diet and lifestyle changes or a combination of approaches have ... successfully worked at treating depression.
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