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Vitamin B 12: Deficiencies
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American ChronicleDoes Tanning Combat Vitamin D Deficiency?American Chronicle, CA - 16 hours agoMore importantly, did you know that sun tanning can actually help to combat a Vitamin D deficiency? It s true. You see, Vitamin D is sometimes called the ...Are Tanning Beds a Safe Alternative to Sunlight? American ChronicleAre Tanning Beds a Safe Source of Vitamin D? American Chronicleall 17 news articles
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Vitamin B12 deficiency may take decades to develop, and affected patients may be asymptomatic or may present with a wide spectrum of hematologic and neuropsychiatric manifestations. Herbert (1) outlined four stages in the development of vitamin B12 deficiency. Stages 1 and 2 represent conditions in which the biochemical depletion of vitamin B12 occurs prior to any obvious clinical damage; serum B12 levels may still be normal. Stages 3 and 4 represent conditions of true deficiency with obvious metabolic components, clinical components, or both; serum B12 levels are low, and serum MMA and homocysteine levels are high. Any hematologic and neurologic features tend to occur in the late stages (1).
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Observational studies have found as many as 30% of patients hospitalized for depression are deficient in vitamin B12 (36). A cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B12 deficient women were twice as likely to be severely depressed as non-deficient women (37). A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B12 status (38). The reasons for the relationship between vitamin B12 deficiency and depression are not clear but may involve S-adenosylmethionine (SAMe). Vitamin B12 and folate are required for the synthesis of SAMe, a methyl group donor essential for the metabolism of neurotransmitters whose bioavailability has been related to depression. This hypothesis is supported by several studies that have shown supplementation with SAMe improves depressive symptoms (39-42).
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HealthScout - Disorders such as vitamin deficiency, infection, or hydrocephalus can be treated with specific therapies that can reverse the symptoms in some cases. In most of the progressive dementias, such as Alzheimer's disease, a specific cure is lacking
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MINNEAPOLIS, MINNESOTA Pernicious anaemia can be treated with intramuscular injections of cobalamin (vitamin B12). These injections can be painful and expensive, but are still widely used despite the fact that research done 30 years ago clearly established that oral doses of one mg/day of vitamin B12 are effective in treating pernicious anaemia and other cobalamin deficiency disorders. The problem. according to Dr. Frank Lederle. MD of the Minneapolis Veterans Affairs Medical Center, is that physicians are unaware that oral cobalamin works. Dr. Lederle performed a survey among Minneapolis internists in 1989 and again in 1996.
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Nitrous oxide, a commonly used anesthetic, inhibits both of the vitamin B12- dependent enzymes and can produce many of the clinical features of vitamin B12 deficiency, such as megaloblastic anemia or neuropathy. Because nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B12 deficiency should be ruled out prior to its use (4, 12).
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