LYCOS RETRIEVER 
Vincristine
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Vincristine Sulfate Injection is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Originally known as leurocristine it has ... been referred to as LCR and VCR. The molecular formula for vincristine sulfate is C46H56N4O10 H2SO4. It has a molecular weight of 923.04.
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Vincristine is in the FDA pregnancy category D. This means that vincristine is known to be harmful to an unborn baby. Do not use vincristine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with vincristine. It is not know whether vincristine passes into breast milk. Breast-feeding should be avoided during treatment with vincristine.
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Vincristine has some potential for neurologic side effects, especially in cats. A neurologically based constipation may result. Difficulty coordinating the feet may be seen. Humans report paresthesias, which include odd sensations such as occur when one's foot is "asleep."
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The improper administration of the powerful cancer drug Vincristine has lead to deaths or permanent paralysis in a number of patients. The fatal results occur when the drug is administered through a spinal catheter rather than being injected into a vein.The confusion is explained in part by the fact that the spinal catheter method is used for other drugs given to leukemia and lymphoma patients.
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Vincristine may cause harm to a fetus when administered to pregnant women. Only in life-threatening situations, should this treatment be used during pregnancy. Women of childbearing age are advised not to become pregnant during treatment. Women should stop nursing before beginning treatment, due to the potential for serious adverse side effects in the nursing infants.
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Lowered resistance to infection Vincristine can reduce the production of white blood cells by the bone marrow, making you more prone to infection. This effect can begin seven days after treatment has been given, and your resistance to infection usually reaches its lowest point 10–14 days after chemotherapy. Your blood cells will then increase steadily and will usually have returned to normal levels before your next cycle of chemotherapy is due.
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Vincristine