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Vicodin: Hydrocodone
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In the second comparison, that of NRP290 (1 x 24mg) to Vicodin (2 x 5/500mg), the 90% confidence intervals for peak of hydrocodone based on ln(Cmax) was within 80% to 125%. The upper limit of 90% confidence intervals for overall exposure parameters of hydrocodone based on ln(AUClast) and ln(AUCinf) were slightly higher (128.51% and 134.67%).
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In the U.S. there are over 200 products containing hydrocodone, typically combined with acetaminophen (Vicodin, Lortab). However, it is ... combined with aspirin (Lortab ASA), ibuprofen (Vicoprofen), and antihistamines (Hycomine). Both tablet and liquid forms of hydrocodone are available (Tussionex). Other brand names include Anexsia, CoGesic, Hydrocet, Hy-Phen, Lorcet, Maxidone, Norco, Panacet, and Zydone. Street names for Vicodin include vikes and hydros.
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In 2000, the National Institute on Drug Abuse listed hydrocodone (the narcotic ingredient in Vicodin) as an “emerging” recreational drug. Its use has risen steadily each year, and has now achieved the status of no longer being “emerging.”
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