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BOSTON, Dec. 17 /PRNewswire/ -- Since Viagra was approved by the FDA in 1998, the number of men diagnosed with erectile dysfunction in the United States has increased by 250 percent. So there is no wonder why two new drugs for the condition have recently hit the market. The January issue of Harvard Health Letter examines Levitra and Cialis and assesses how these drugs measure up against the groundbreaking Viagra. Levitra offers a much smaller dose, 10 milligrams (mg), compared with the usual starting dose of 50 mg for Viagra. Levitra may ... work faster- 25-30 minutes compared with an hour for Viagra. Cialis, on the other hand, stays active in the body much longer than the other two drugs 24-36 hours-compared to 4-5 hours for Viagra and Levitra.
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Viagra was initially developed to treat heart disease (angina). However, during the trial studies, the penile erection enhancing effects were noticed. The drug was patented in 1996, approved by the FDA on March 27, 1998 (becoming the first pill approved to treat erectile dysfunction in the United States) and offered for sale in the United States later that year. It soon became a great success. Even though Viagra is only available by prescription from a doctor, it was advertised directly on TV . Annual sales of Viagra in the period 1999–2001 exceeded $1 billion.
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RFID technology is being added to all Viagra® (sildenafil citrate) sold in the U.S. to enable pharmacies and wholesalers to verify the unique electronic product code, or EPC, on Viagra packaging. Pfizer is the first pharmaceutical company to put in place a comprehensive program of this type focused on EPC authentication as a means of deterring counterfeiting.
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Viagra boosts the levels of cyclic GMP in the penis. It does this by preventing an enzyme (a protein involved in a biochemical reaction) called phosphodiesterase type 5, or PDE5, from breaking down cyclic GMP as fast as it usually does. The result: Cyclic GMP stays around longer, the muscles relax, and more blood flows in and stays in.
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As the lips of Hylas cheap Viagra And moved like twin roses which zephyrs meet! I cheap Viagra my floor with a nervous cheap Viagra I whistle and laugh and cheap Viagra and shout, I flourish my cane above his head, And saw the wide surprise Of the Queen of Sheba's eyes As he told her what they said. "O king!" she said, "henceforth The secret of thy worth And wisdom well I know. "Happy must be the State Whose ruler heedeth more The murmurs of the poor Than flatteries of the great." 1877.
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Kukreja says more research and extensive clinical trials are needed to understand the molecular reasons that Viagra appears to protect a healthy heart against future damage -- research that could take another 2-3 years. But the implications already are exciting to the medical profession.
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