LYCOS RETRIEVER 
Toprol Xl: Toprol-Xl
built 642 days ago
On January 17, 2006 Judge Rodney Sippel of the U.S. District Court for the eastern district of Missouri has ruled under summary judgment in favor of the generic challengers, clearing their way to launch generic versions of Toprol-XL in U.S. market. This is... a pyrrhic victory for generic manufactures after successive para IV defeats in Lipitor (Atorvastatin Calcium, Ranbaxy losing to Pfizer), Accupril (Quinapril Hydrochloride, Ranbaxy losing to Pfizer), Norvasc (Amlodipine Besylate, Dr. Reddy’s loses to Pfizer) and Zyprexa (Olanzapine, Dr. Reddy’s loses Eli Lilly). The court has favored suits filed by KV Pharmaceutical Co, Andrx Corp. and Eon Labs Inc. (a unit of Novartis AG), challenging the validity and enforceability of Orange Book listed patents. Astra, which earlier contended before the District Court that its patents on Toprol-XL will survive their patent term, has now announced their intention to appeal against the judgment in the U.S. Court of Appeals for the Federal Circuit maintaining that both US patents (5001161 and 5081154) are valid and enforceable.
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TOPROL-XL is indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digitalis. In this population, TOPROL-XL decreased the rate of mortality plus hospitalization, largely through a reduction in cardiovascular mortality and hospitalizations for heart failure.
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If you have an allergic reaction while taking Toprol-XL you need to seek medical attention immediately. Signs of an allergic reaction include hives, trouble breathing, and swelling of the lips, tongue, throat, lips, and face.
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The dosage of TOPROL-XL should be individualized. The usual initial dosage is 100 mg daily, given in a single dose. The dosage may be gradually increased at weekly intervals until optimum clinical response has been obtained or there is a pronounced slowing of the heart rate. Dosages above 400 mg per day have not been studied. If treatment is to be discontinued, the dosage should be reduced gradually over a period of 1–2 weeks (see WARNINGS).
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In Merit-HF, almost 4000 patients with moderate-to-severe heart failure from 14 countries were randomized to once-daily doses of placebo or Toprol-XL, titrating from 12.5 mg or 25 mg to 200 mg per day over six weeks. In the U.S., more than 1000 patients participated. The main aim of the study was to investigate the impact of metoprolol succinate extended release compared with
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The usual starting dosage is a total of 100 milligrams a day taken in 2 doses of Lopressor or a single dose of Toprol-XL. Your doctor may gradually increase the dosage up to 400 milligrams a day.
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Toprol-Xl