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Sotalol
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Sotalol is a drugknown as a beta-blocker. Sotalol works by blocking the response of certain nerve impulses and adrenaline-like substances in the body. Sotalol is used to treat serious heart rate irregularities.
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Sotalol is a non-cardioselective beta adrenergic blocking drug with Class II antiarrhythmic effects. In addition, sotalol prolongs the duration of the cardiac action potential and is ... classified as a Class III antiarrhythmic agent similar to amiodarone.
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Sotalol hydrochloride does not bind to plasma proteins and is not metabolised. The pharmacokinetics of the d- and l- enantiomers of sotalol hydrochloride are essentially identical. Sotalol hydrochloride crosses the blood-brain barrier poorly, with cerebrospinal fluid concentrations being 5%-28% of those observed in plasma. Sotalol is excreted by glomerular filtration and to a small extent by tubular secretion. Approximately 80 to 90% of a dose is excreted unchanged in the urine, while the remainder is excreted in the faeces. Lower doses are necessary in renally impaired patients.
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Sotalol belongs to a group of medicines known as beta-blockers. Sotalol is used to treat hypertension and to relieve angina (chest pain). In heart attack patients it helps prevent additional heart attacks. Sotalol helps correct irregular heartbeat, prevent migraine headaches, and treat tremors. It may ... be used for other circumstances as determined by your doctor.
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Sotalol is frequently used for treatment of ventricular and supraventricular arrhythmias. Its QT-prolonging potential is well studied and mediated predominantly by block of IKrwhich appears to be the target of most antiarrhythmic and non-antiarrhythmic drugs with QT-prolonging potential.10 Hepatic biotransformation of sotalol is limited, and no pharmacologically active metabolites have been identified. Elimination occurs via the renal route, with 75–90% of an oral or intravenous dose being recovered in the urine within 48h of administration. The plasma elimination half-life of sotalol is 6–15h on acute administration. Obesity or hepatic impairment does not significantly modify the pharmacokinetic properties of sotalol, while renal insufficiency accounts for major sotalol accumulation. In patients withnormal renal function, D,L-sotalol seemed the most suitable drug to challenge repolarization stability by blocking IKrin a controlled way.
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Sotalol is given as tablets, which may be supplemented with injections in emergencies to control abnormal heart beats. Occasionally sotalol is given as an injection only, either during tests to investigate abnormal heartbeats, or as a temporary substitution for tablets.
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Sotalol