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Sinusitis: Surgery
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Click to see larger picture Goshen and associates performed bone and gallium scans of the sinus regions in 32 patients presenting with frontal sinusitis. Bone scans classified according to 99Tc methylene diphosphonate (MDP) distribution patterns indicated active and resolving sinusitis, as well as surgery-related bone trauma. However, the intensity of gallium uptake was well correlated with the final outcome. This uptake was useful for differentiating between active and resolving sinusitis, with more specifically than that of the corresponding bone scans. Thus, combined studies may have a role in the diagnosis and management of frontal sinusitis.
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Allergic fungal sinusitis is currently treated with oral corticosteroids such as prednisone, but researchers are investigating whether anti-fungal drugs may help. The anti-fungal drug Amphotericin B (SinuNase) is currently in Phase III trials for patients with chronic sinusitis who have had sinus surgery but are still experiencing sinusitis symptoms. However, several 2006 studies indicated disappointing results.
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A nonenhanced coronal CT viewed in a bone window provides excellent resolution and good definition of the complete osteomeatal complex and other soft-tissue abnormalities seen in sinusitis. The coronal view is best correlated with findings from sinus surgery. Contrast-enhanced CT may be required in cases of acute sinusitis complicated by periorbital cellulitis or abscess.
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A CT scan can pinpoint the physical cause of chronic sinusitis. It may show the cause to be polyps, enlargements of certain areas of the sinus, a deviated septum, or chronically inflamed tissue. At The New York Eye and Ear Infirmary, a special "real time" imaging device, which displays a 3-D image of the patient's sinus cavity based on the CT scans, helps Dr. Schaefer and his colleagues to visualize and locate the surgical site during endoscopic sinus surgery. In most circumstances, surgery corrects these problems.
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Scientists are investigating whether antifungal drugs may help treat chronic sinusitis. One such drug, Amphotericin B (SinuNase), is currently in Phase III trials for patients who have had sinus surgery but are still experiencing recurrent sinusitis. Results from previous clinical trials have been mixed.
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Chronic sinusitis is often treated at first with antibiotics; steroid nasal sprays may be used to decrease swelling in the nasal passages. If an anatomicreason is found for chronic sinusitis, it may need to be corrected with surgery.
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