LYCOS RETRIEVER 
Sarcoidosis: Treatments
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Since sarcoidosis was last reviewed in the Journal 10 years ago,2 more than 5000 articles related to this condition have been published. This review summarizes recent advances and addresses pitfalls in the diagnosis and treatment of sarcoidosis.
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Treatment of cardiac sarcoidosis with corticosteroids is likely to be beneficial but is not well described in the literature. Surgical options include placement of pacemakers or cardioverter-defibrillators, resection of affected areas of the heart, and cardiac transplantation.
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Researchers continue to examine the role of steroids in the treatment of sarcoidosis, with some addressing the question of what effect they may have on the long-term course of the disease. However, in general, steroid therapy remains the leading treatment for sarcoidosis.
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Infliximab and thalidomide have been used for refractory sarcoidosis, particularly for cutaneous disease. Infliximab appears to be an effective treatment for patients with systemic manifestations such as lupus pernio, uveitis, hepatic sarcoidosis, and neurosarcoidosis.
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There is no cure for sarcoidosis, but the disease may get better on its own over time or with drug therapy. Drug treatments are used to relieve symptoms, reduce the inflammation of the affected tissues, reduce the impact of granuloma development, and may prevent the develop-ment of lung fibrosis or other irreversible organ damage.
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