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Sarcoidosis: Sarcoidosis Clinic
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Sarcoidosis is a multisystem granulomatous disease which was first described by Jonathan Hutchinson in 1878. Its clinical manifestations and course can be variable in different ethnic groups. The organs affected more often are the lungs, skin and eyes.
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INTRODUCTION — Sarcoidosis is a systemic granulomatous disease of unknown etiology, characterized by the formation of noncaseating granulomas. Clinically recognizable gastrointestinal (GI) system involvement occurs in 0.1 to 0.9 percent of patients with sarcoidosis, although the incidence of subclinical involvement may be much higher. The stomach is the most commonly involved portion of the GI tract, but sarcoidosis of the esophagus, appendix, colon, rectum, and pancreas have ... been described [1-5].
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Sarcoidosis enters into any physicians' differential diagnosis of a systemic illness with no obvious cause. The disease is more common in males and is ten times more frequent in American blacks. The disease may be discovered incidentally on routine chest radiographs as bilateral lung hilar lymphadenopathy. However, any organ can be involved and almost every clinical presentation has been documented depending upon the organs affected. The clinical course is unpredictable but 65-70% may recover with minimal residual changes. Permanent loss of lung function may occur in 20%.
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Sarcoidosis is often referred to as the "snowflake" disease because patients present with so many different symptoms. The clinical picture can be complicated by intermittent inflammation in many different organs. While the symptoms may vary from patient to patient, the underlying cause is the same. The disease is really very simple when you realize that sarcoidosis inflammation has only one cause: intracellular bacteria. The MP is designed to deal with all intra-phagocytic bacteria, regardless of the species.
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The staff of the Sarcoidosis Clinic at Boston Medical Center is comprised of two physicians with expertise in sarcoidosis and a dedicated clinic staff, including two nurse clinicians experienced in sarcoidosis. The clinic is directed by Jeffrey S. Berman, Professor of Medicine at Boston University School of Medicine and an acknowledged expert in the diagnosis, treatment, and investigation of sarcoidosis. Dr. David M. Serlin was a 2005 recipient of a Young Investigator Award at the most recent meeting of the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) held in Denver, CO. Drs. Berman and Serlin are active members of WASOG.
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Current research activities of the Sarcoidosis Clinic and research program include 1. studies of how the immune system functions in the development of sarcoidosis; 2. studies of the genes involved in sarcoidosis; 3. studies on how to best evaluate and treatsarcoidosis with a focus on difficult problems such as advanced lung disease or other organ involvement.
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Sarcoidosis Clinic