LYCOS RETRIEVER 
Sarcoidosis: Granulomas
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Sarcoidosis (sar"koi-do'sis) involves inflammation that produces tiny lumps of cells in various organs in your body. The lumps are called granulomas (gran"u-lo'mahs) because they look like grains of sugar or sand. They are very small and can be seen only with a microscope.
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Sarcoidosis is an inflammatory disease that affects multiple organs in the body, most commonly the lungs and lymph glands. The condition is characterized by the development of abnormal masses—nodules or granulomas—consisting of inflamed tissue that can alter the normal structure and function of the affected organ.
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Sarcoidosis Sarcoidosis is a multisystem disease, characterized by the presence of noncaseating granulomas in various organs (granulomas are a type of localizaded tissue inflamation). It generally affected the lungs (in more than 90% of the cases), but can have a large variety of syntoms.
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Sarcoidosis is a "multiorgan" disease - meaning it almost always involves more than one organ. An organ is affected when granulomas (masses of inflamed tissue, or lumps) form and cause an abnormality.
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Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Sarcoidosis is manifested by the presence of noncaseating granulomas (NCGs) in affected organ tissues.
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Biopsy remains the most important diagnostic procedure in children with sarcoidosis. Enlarged lymph nodes are an appropriate site for biopsy, but if none is present, biopsy of the scalene fat pad is most likely to reveal a lesion compatible with sarcoidosis. A conjunctival biopsy is good when typical nodules are present but the yield drops from 75% to 25% when they are absent. An enlarged parotid, skin, liver, muscle, tendon sheath, and minor salivary glands have all been biopsied. The classic biopsy finding is a noncaseating granuloma composed of epithelial cells and occasional Langerhans giant cells, lymphocyte, macrophages, and fibroblasts may surround the granuloma. Inclusion bodies are frequently observed within giant cells.
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Granulomas