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Sarcoidosis: Breathing
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Sarcoidosis can affect the cranial nerves (nerves of the head), causing double vision and making one side of the face droop. If the pituitary gland or the bones surrounding it are affected, diabetes insipidus (see Pituitary Gland Disorders: Central Diabetes Insipidus) may result. The pituitary gland stops producing
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Some physicians believe that sarcoidosis may result from a respiratory infection caused by a virus. Others suspect that exposure to toxins or allergens in the environment is to blame. Researchers are looking for answers to this and many other questions about sarcoidosis.
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During 1971-1993, the average annual age-specific incidence rate for sarcoidosis declined substantially among USN enlisted black men aged 21-30 years, from 73.3 per 100,000 to 13.2 per 100,000 (Figure_1). Rates for enlisted black men aged 31-40 years declined from 46.5 to 27.8, primarily during 1991-1993. During 1971-1993, rates for USN enlisted white men remained relatively stable.
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"Alveolar interstitial infiltration of macrophages and lymphocytes is present in the early phases of sarcoidosis and may precede granuloma formation. It appears to be inversely related to the frequency of granulomas." Rosen, 1978
Dr. Sharma, professor of Medicine at the University of Southern California School of Medicine and sarcoidosis specialist, has an extensive collection of "Spy" portraits on display in his office. The caricature of Hutchinson holds a prominent position on his wall. In 1877, this English physician was the first to describe sarcoidosis.
While the cells involved in forming granulomas are known, the events that trigger their formation in sarcoidosis are not. These triggering and perpetuating factors are being investigated. Ultimately, the hope is that this will allow sarcoidosis to be prevented or treated more effectively in the future.
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