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Rohypnol: Effects
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Rohypnol is lipophlic and when it is ingested, it is absorbed quickly into the bloodstream and enters the brain via oxidative pathways. The chemical is metabolised rapidly by enzymes (main one being CYP3A4) and binds to nerve receptors that are involved in co-ordination, memory and anxiety. In the absence of Rohypnol, the GABA neurotransmitter binds to these nerve receptors and reduces the activity in the brain. However, when Rohypnol is present it binds to another site (not the binding site) of GABA which slows down the nerve activity in the brain more efficiently. This enhancement of the GABA effect makes Rohypnol a ‘positive allosteric modulator’.
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Among the immediate effects of taking Rohypnol are feelings of intoxication, muscle relaxation, and drowsiness. Users under the influence may exhibit slurred speech, impaired judgment, and difficulty in walking. The drug causes “anterograde amnesia,” whereby individuals are unable to remember events they experienced while under its effects.
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Rohypnol is addictive; and habitual use, even for just a few weeks, can lead to physical and psychological dependence. Significant tolerance to Rohypnol can ... develop. Sudden withdrawal is dangerous because the central nervous system has adapted to the drug's effects. It's important to seek medical help if you are addicted to Rohypnol because of the dangerous withdrawal symptoms. These symptoms can occur a week or more after cessation of use and may include:
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Under Rohypnol, individuals may experience a slowing of psychomotor performance, muscle relaxation, decreased blood pressure, sleepiness, and/or amnesia. Some of the adverse side effects associated with the drug’s use are drowsiness, headaches, memory impairment, dizziness, nightmares, confusion, and tremors. Although classified as a depressant, Rohypnol can induce aggression and/or excitability
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Rohypnol is 10 times more potent than Valium and enters the bloodstream as quickly as 15 minutes after ingestion. A single 2-milligram pill has the same potency as a 6-pack of beer, but the effects differ slightly. Users can experience extreme sedation, dizziness, and loss of bodily control.
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