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Risperidone
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Risperidone may help control your symptoms but will not cure your condition. It may take several weeks or longer before you feel the full benefit of risperidone. Continue to take risperidone even if you feel well. Do not stop taking risperidone without talking to your doctor. If you suddenly stop taking risperidone, your symptoms may return and your illness may become harder to treat.
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Risperidone could be subject to two kinds of drug-drug interactions. First, inhibitors of cytochrome P450IID6 could interfere with conversion of risperidone to 9-hydroxyrisperidone. This in fact occurs with quinidine, giving essentially all recipients a risperidone pharmacokinetic profile typical of poor metabolizers. The favorable and adverse effects of risperidone in patients receiving quinidine have not been evaluated, but observations in a modest number (n is approximately equal to 70) of poor metabolizers given risperidone do not suggest important differences between poor and extensive metabolizers. It would ... be possible for risperidone to interfere with metabolism of other drugs metabolized by cytochrome P450IID6. Relatively weak binding of risperidone to the enzyme suggests this is unlikely (See PRECAUTIONS and DRUG INTERACTIONS).
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Risperidone may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking risperidone.
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Risperidone is an antipsychotic agent belonging to a new chemical class, the benzisoxazole derivatives. The chemical designation is 3-(2-(4-(6- fluoro- 1,2-benzisoxazol- 3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro- 2- methyl-4H-pyrido(1,2-a)pyrimidin-4-one. Its molecular formula is C23H27FN4O2 and its molecular weight is 410.49. Risperidone is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0.1 N HCl.
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Risperidone is ... approved to treat children and adolescents (ages 5-16 years) who have irritability associated with autistic disorder. Risperidone can improve symptoms of autistic disorder such as: aggression toward others, self-injurious behaviors, temper tantrums, and rapidly changing moods.
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Antipsychotic efficacy was demonstrated in a dose range of 4 to 16 mg/day in the clinical trials supporting effectiveness of Risperidone... maximal effect was generally seen in a range of 4 to 6 mg/day. Doses above 6 mg/day were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other adverse effects, and are not generally recommended. The safety of doses above 16 mg/day has not been evaluated in clinical trials.
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Risperidone