LYCOS RETRIEVER 
Risperidone: Serotonin
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Risperidone is a benzisoxazole antipsychotic, mixed serotonin-dopamine antagonist that binds to 5-HT2-receptors in the CNS and in the periphery with a very high affinity; binds to dopamine-D2 receptors with less affinity. The binding affinity to the dopamine-D2 receptor is 20 times lower than the 5-HT2 affinity. The addition of serotonin antagonism to dopamine antagonism (classic neuroleptic mechanism) is thought to improve negative symptoms of psychoses and reduce the incidence of extrapyramidal side effects. Alpha1, alpha2 adrenergic, and histaminergic receptors are ... antagonized with high affinity. Risperidone has low to moderate affinity for 5-HT1C, 5-HT1D, and 5-HT1A receptors, weak affinity for D1 and no affinity for muscarinics or beta1 and beta2 receptors
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Risperidone works in the brain, where it affects various neurotransmitters, in particular dopamine and serotonin (5HT). Neurotransmitters are chemicals that are stored in nerve cells and are involved in transmitting messages between the nerve cells.
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Risperidone works by affecting the action of two important nerve transmitters in the brain, dopamine and serotonin. This corrects an underlying imbalance believed to be responsible for a number of mental disorders.
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Serotonin