LYCOS RETRIEVER
Risperidone: Patients
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Risperidone is used to treat the symptoms of psychotic disorders, such as schizophrenia, mania or bipolar disorder, or irritability associated with autistic disorder. This medicine should NOT be used to treat behavioral problems in older adult patients who have dementia .
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POTENTIAL FOR COGNITIVE AND MOTOR IMPAIRMENT: Somnolence was a commonly reported adverse event associated with Risperidone treatment, especially when ascertained by direct questioning of patients. This adverse event is dose related, and in a study utilizing a checklist to detect adverse events, 41% of the high dose patients (Risperidone 16 mg/day) reported somnolence compared to 16% of placebo patients. Direct questioning is more sensitive for detecting adverse events than spontaneous reporting, by which 8% of Risperidone 16 mg/day patients and 1% of placebo patients reported somnolence as an adverse event. Since Risperidone has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Risperidone therapy does not affect them adversely.
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Risperidone is one of the most commonly prescribed anti-psychotic medications around the world. Atypical anti-psychotics such as risperidone have a much lower incidence of extra-pyramidal symptoms than the older agents like haloperidol.[1] Dysphagia is a very uncommon side-effect of risperidone and very few reports are available in the literature.[2] We would like to report a case of dysphagia occurring in a patient with schizophrenia while on treatment with risperidone.
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There is no specific antidote to Risperidone. Therefore appropriate supportive measures should be instituted. The possibility of multiple drug involvement should be considered. Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids and/or sympathomimetic agents (epinephrine and dopamine should not be used, since beta stimulation may worsen hypotension in the setting of risperidone-induced alpha blockade). In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision and monitoring should continue until the patient recovers.
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