LYCOS RETRIEVER 
Risperidone: Doses
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Risperidone is an antipsychotic agent of a class often referred to as atypical. It should be noted that the definition of the term “atypical” is not universally agreed upon. Some prefer to describe antipsychotics based on their pharmacological properties. A common feature of all definitions used to describe “atypical” antipsychotics is the lack of significant acute or subacute EPS, at dosages generally associated with antipsychotic actions. Other experts have included definitions of atypicality that include a) failure to increase serum prolactin levels; b) superior efficacy for positive, negative, and cognitive symptoms; and c) lack of evidence of tardive dyskinesia or dystonia following chronic administration. Risperidone meets the low EPS criteria at low doses (<6 mg/day).
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Risperidone is a relatively new antipsychotic available world-wide since the early 1990s. It has been characterised as atypical, but shares some of the extrapyramidal side effect profile of the earlier antipsychotics, particularly at higher doses.
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The effectiveness of Risperidone in long-term use, that is, more than 6 to 8 weeks, has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use Risperidone for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (See DOSAGE AND ADMINISTRATION).
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