LYCOS RETRIEVER 
Rifampin
built 642 days ago
Pharmacology: Rifampin is a semisynthetic derivative of rifamycin B, an antibiotic produced by Streptomyces mediterranei. Rifampin is active against microorganisms of the genus Mycobacterium, including M. tuberculosis, M. kansasii, M. marinum, M. avium-intracellulare (M. avium complex) and M. leprae. Rifampin is ... active against some gram-negative bacteria including N. meningitidis and H. influenzae type b, in addition to some gram-positive bacteria including S. aureus and S. epidermidis. Because of rapid emergence of resistant strains, it is generally recommended that rifampin be used in combination with other antibacterial agents.
Source:
Rifampin is a semisynthetic antibiotic derivative of rifamycin SV. Rifampin is a red-brown crystalline powder very slightly soluble in water at neutral pH, freely soluble in chloroform, soluble in ethyl acetate and in methanol. Its molecular weight is 822.95 and its chemical formula is C 43 H 58 N 4 O 12 . The chemical name for rifampin is either:
Source:
Rifampin can cause serious liver problems, especially if you are ... taking pyrazinamide (PZA). Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your prescriber or other health care provider. Visit your prescriber or health care professional for regular checks and report any serious side effects promptly.
Rifampin is a derivative of rifamycin that suppresses RNA synthesis, resulting in broad antimicrobial properties. When rifampin is used as monotherapy, resistance develops rapidly because of single-point mutations. In combination therapy, rifampin has many important applications. It exhibits good activity against many gram-positive cocci (including methicillin-resistant Staphylococcus aureus), some gram-negative organisms, Legionella, many mycobacteria and some fungi.
Source:
Rifampin targets the β subunit of DNA-directed RNA polymerase by inhibiting extension of the RNA strand. The β subunit is encoded by the rpoB gene. Previous studies have demonstrated that one of the mechanisms of rifampin resistance in Neisseria meningitidis is associated with single point mutations of the rpoB gene that result in amino acid substitutions (11–13). The data presented in this study confirm the rapid development of rifampin resistance upon exposure of meningococci to rifampin as a result of point mutations in the rpoB gene.
Source:
Rifampin is very lipophilic and penetrates most body tissues (including bone and prostate), cells and fluids (including CSF) well. It ... penetrates abscesses and caseous material. Rifampin is 70-90% bound to serum proteins and is distributed into milk and crosses the placenta. Mean volume of distribution is approximately 0.9 L/kg in horses, and 1.3 L/kg in sheep.
Source:
MORE ABOUT
Rifampin