LYCOS RETRIEVER 
Rhinitis: Asthma
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Patients with occupational rhinitis have symptoms of rhinitis only in the workplace. These symptoms are usually due to an inhaled irritant (eg, metal salts, animal dander, latex, wood dusts, chemicals). Patients with occupational rhinitis frequently present with concurrent occupational asthma. The diagnosis is based on the history or the results of nasal provocation or skin testing. Avoidance is preferable, but this is often not achievable. In the situations, nasal corticosteroids or second-generation antihistamines have been of use.
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Inhaled corticosteroids (ICS) are regarded today as the gold standard in asthma and allergic rhinitis therapy. They inhibit the activity of pro-inflammatory cells and promote the endogenous production of anti-inflammatory substances. With regular use of these corticosteroids, the inflammation in the lungs and airways that underlies the asthma is attenuated.
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Allergic rhinitis can be associated with a number of comorbid conditions, including asthma, atopic dermatitis, and nasal polyps. Evidence now suggests that uncontrolled allergic rhinitis can actually worsen the inflammation associated with asthma or atopic dermatitis. This could lead to further morbidity and even mortality.
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Accurate diagnosis of allergic rhinitis is important because many problems have similar symptoms (such as upper respiratory tract infections). Finding what causes your symptoms can help your doctor find the best treatment for you. Your doctor can ... see if you have complications, such as sinusitis or asthma.
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The global non-steroidal market for the treatment of asthma and rhinitis is currently worth in excess of US $4 billion; prescriptions for the treatment of rhinitis contribute 15% to total worldwide sales of non-steroidals. A FLAP inhibitor with improved efficacy and equal or improved safety and tolerability to existing leukotriene receptor antagonists, in both asthma and rhinitis, would likely capture a significant portion of this market.
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There is usually a family history of allergic rhinitis. This disease affects up to 20 percent of children and 15 to 30 percent of adolescents. It is estimated that 75 percent of children with asthma ... have allergic rhinitis.
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Asthma