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Rheumatoid Arthritis: Morning
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The global obesity epidemic has been issued with a further health warning - that obesity exacerbates the quality of life of patients with rheumatoid arthritis (RA). New data presented at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain, shows that RA in obese patients is associated with worse quality of life outcomes on four key levels: pain, fatigue, physical function and overall utility scores. [click link for full article] ...more
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This is a great example of a rare case of rheumatoid neutrophilic dermatosis. This patient had severe rheumatoid arthritis and developed plaques and bulla over the forearms. Rheumatoid neutrophilic dermatosis is a rare manifestation of severe joint disease, as in this case. Histologically, this is one of the neutrophilic dermatoses along with Sweet syndrome, cellulitis, pyoderma gangrenosum and others. The bulla are often secondary, and not always seen. Distinction between these entities is virtually impossible without clinical history.
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ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderate to severe rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.
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Experts recommend early treatment with medicines that may control rheumatoid arthritis or keep it from getting worse. Early treatment ... may lower the chances that inflammation will destroy your joints and limit your daily activities.
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[O]bserved in patients treated with TACI-Ig were schedule and dose-dependent reductions of IgM, IgA and IgG and of rheumatoid factor, a biologic marker of disease. In the cohort of 19 patients that received seven doses of TACI-Ig over a three-month period, positive trends on some disease activity measures such as ACR 20 and DAS 28 were ... noted.
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The EULAR criteria for rheumatoid arthritis use the disease activity scale (DAS) using the 28-joint tender and swollen joint counts, which includes not only change in disease activity but ... current disease activity. To be classified as responders, patients should have a significant change in DAS and also low current disease activity. Patients are classified as good, moderate, or non-responders according to both a significant change in the DAS and the level of residual disease activity.
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