LYCOS RETRIEVER 
Rheumatoid Arthritis: Inflammation
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In rheumatoid arthritis, multiple joints are usually inflamed in a symmetrical pattern (both sides of the body affected). The small joints of both the hands and wrists are often involved. Simple tasks of daily living, such as turning door knobs and opening jars can become difficult during flares. The small joints of the feet are ... commonly involved. Occasionally, only one joint is inflamed. When only one joint is involved, the arthritis can mimic the joint inflammation caused by other forms of arthritis, such as gout or joint infection.
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When rheumatoid arthritis develops slowly, it may first attack the small joints of the hands and feet with swelling. In more severe or advanced cases, other areas of the body can become inflamed, including the eyes, blood vessels, lungs, heart, and nerves. Rheumatoid Arthritis may make you run a fever and ache all over. You may become anemic, and have dryness of the eyes and mouth caused by inflammation of the tear ducts and salivary glands.
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ENBREL is a treatment for moderate to severe rheumatoid arthritis. It is a man-made protein similar to proteins that occur naturally in the body that fight rheumatoid arthritis. It attaches to TNF and helps block the process that can lead to the pain, inflammation, and progression of joint damage that rheumatoid arthritis can cause. Because of the effects of ENBREL on the immune system, it can raise important safety considerations. Be sure to read Important Product Information and talk to your doctor.
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IL-1 and tumor necrosis factor (TNF) are cytokines that have been directly linked to the progression of inflammatory diseases including rheumatoid arthritis and chronic inflammatory bowel diseases, such as Crohn's Disease. Hyseq's IL-1Hy1 and IL-1Hy2 are receptor antagonist family members. Receptor antagonists have been identified with activity that block IL-1 cytokines from binding to cell receptors thereby inhibiting inflammation. Hyseq's IL-1 receptor antagonists are potential therapeutic candidates for inhibiting IL-1 binding activities and arresting inflammatory progression.
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The exact cause of rheumatoid arthritis is not known. Rheumatoid arthritis is an autoimmune disorder, which means the body's immune system attacks its own healthy cells and tissues. The response of the body causes inflammation in and around the joints, which then may lead to a destruction of the skeletal system. Rheumatoid arthritis ... may have devastating effects to other organs, such as the heart and lungs. Researchers believe certain factors, including heredity, may contribute to the onset of the disease.
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Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and deformity of the joints. Other problems throughout the body (systemic problems) may ... develop, including inflammation of blood vessels (vasculitis), the development of bumps (called rheumatoid nodules) in various parts of the body, lung disease, blood disorders, and weakening of the bones (osteoporosis).
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