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Restless Leg Syndrome: Conditions
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Both Restless Leg Syndrome (RLS) and Periodic Limb Movement (PLM) are sleep disorders which can lead to insomnia and subsequent fatigue during the day. These disorders worsen slowly over time, and as the condition deteriorates, the arms may ... become involved.
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Regulators have approved the first U.S. treatment for restless legs syndrome, a condition that can disrupt sleep and daily activities. The neurological condition, which involves a compelling urge to move the legs, affects one in 20 adults in the United States and is a cause of insomnia. Although its exact cause is unknown, researchers believe it may be related to dopamine, a chemical that carries the signals between nerve cells that control body movement. Glaxo, Europe's biggest drug maker, said the drug Requip (ropinirole) works by stimulating dopamine receptors in the brain. The U.S. Food and Drug Administration approved the drug for use in moderate to severe cases of restless legs syndrome. Requip is already a treatment for Parkinson's disease.
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NEW YORK, July 21 /PRNewswire-FirstCall/ -- Pfizer Inc said today that it is ceasing the clinical development of sumanirole, a compound under investigation for the treatment of Parkinson's disease and Restless Leg Syndrome. The decision is based on results of recent studies that failed to sufficiently distinguish sumanirole from currently available therapies. While the compound may still prove effective in these conditions, it did not meet Pfizer's criteria for continued development. Today's statement is an update to the company's second quarter business performance conference call with financial analysts and media on July 21, 2004.
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In addition to synonyms and related conditions, physicians may refer to restless leg syndrome using certain coding systems. The International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) is the most commonly used system of classification for the world’s illnesses. Your physician may use this coding system as an administrative or tracking tool. The following classification is commonly used for restless leg syndrome:
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Restless leg syndrome is a condition which keeps its sufferers from getting a good nights sleep. It cause is not completely known but its symptoms are very real and often times debilitating.
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"Night terrors and such conditions as sleepwalking, restless leg syndrome, bruxism (teeth grinding) make up a group of arousal disorders called parasomnias. Night terrors do not occur during REM sleep and are not dreams, although they have nightmarish elements. They occur instead either during deep sleep or in a transitional state between deep and dreaming sleep and are a form of confusional arousal disorder....Night terrors are rare in adults, yet Papolos and Papolos cited a 1999 study by Dr. Maurice Ohayon which found that bipolar disorders and depression with anxiety were the most common factors associated with adults who reported night terrors" (About.com).
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