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Rap
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Stylistically, rap occupies a gray area among speech, prose, poetry, and song. Rap is derived from the griots (folk poets) of West Africa, and Caribbean-style toasting. It ... has precedents in traditional Gaelic music. Modern rap battles, for instance, bear a striking resemblance to the Limerick Game, a traditional Gaelic drinking game in which people compete for notoriety by making up insulting limericks about each other the loser having to buy the next round of drinks. Likewise, puirt a beul, a form of Scottish mouth music was incorporated into Appalachian music and is an early ancestor of modern mouth percussion, or beatboxing. The influence of Scottish and Irish music on hip hop is not direct, since virtually all of the originators of hip hop culture were African American, but were transferred indirectly by way of American roots music.
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Raptor Pharmaceuticals Corp.'s sole business is its 100% ownership of Raptor Pharmaceutical Inc., a development stage biotechnology company which bioengineers novel drugs and drug-targeting platforms derived from the human receptor-associated protein ("RAP") and related proteins. The Company's preclinical programs target cancer, neurodegenerative disorders, infectious diseases and osteoporosis. HepTide(TM) utilizes engineered RAP-based peptides conjugated to drugs to target their delivery to the liver. In neurodegenerative diseases, engineered RAP peptides called NeuroTrans(TM) are currently undergoing evaluation at Stanford University in cell culture and preclinical models for their ability to enhance the transport of molecules from blood to brain. In osteoporosis, Raptor is testing the ability of WntTide, which are Mesd and engineered Mesd-based peptides and act through LRP5, a known determinant of bone density, to combat osteoporosis and increase bone density. In an effort to protect its novel approach, Raptor currently has five patent applications in review in the U.S., and countries in Europe and Asia, as well as two provisional patent applications licensed from Washington University.
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Rap must have flow, which means that the songs must have prosody, cadence and spped. Some rappers today who are well recognized for their ability to keep all of these things in check during their songs are: Snoop Dogg, Busta Rhymes and Method Man. Make sure that you purchase your Rap/Hip-Hop tickets and see one of these rap masters live in concert!
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Rap music originated as a cross-cultural product. Most of its important early practitioners—including Kool Herc, D.J. Hollywood, and Afrika Bambaataa—were either immigrants or first-generation Americans of Caribbean ancestry. Herc and Hollywood are both credited with introducing the Jamaican style of cutting and mixing into the musical culture of the South Bronx. By most accounts Herc was the first DJ to buy two copies of the same record for just a 15-second break (rhythmic instrumental segment) in the middle. By mixing back and forth between the two copies he was able to double, triple, or indefinitely extend the break.
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Based on promising results from ongoing preclinical studies of its RAP liver targeting program, Raptor has initiated a pre-IND program for HepTide(TM) (its liver targeting therapeutic conjugate using the RAP targeting platform). The Company's goal is to file an IND for this therapeutic conjugate with the Food and Drug Administration (the "FDA") by the end of the second calendar quarter of 2008. To help execute this plan the Company has retained Regulatory Professionals, Inc., a regulatory consulting firm experienced in working with the FDA in all aspects of regulatory affairs including preclinical and clinical support for pre- and post-approval products, and preparation and submission of regulatory filings for marketing approval.
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In 1982 Afrika Bambaataa’s “Planet Rock” became the first rap record to use synthesizers and an electronic drum machine. With this recording, rap artists began to create their own backing tracks rather than simply offering the work of others in a new context. A year later Bambaataa introduced the sampling capabilities of the emulator synthesizer on “Looking for the Perfect Beat” (1983).
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