LYCOS RETRIEVER 
Quinine: Patients
built 774 days ago
Quinine is readily absorbed orally, mainly from the upper small intestine. Bioavailability is approximately 80% in healthy subjects. Absorption is almost complete, even in patients with marked diarrhoea. Quinine is ~ 70% to 85% protein bound.
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Quinine-induced agranulocytosis has been reported. It has been confirmed by the inhibition, in vitro, of bone-marrow cell cultures by therapeutic concentrations of quinine (Sutherland et al., 1977). Other abnormalities include: Coombs' positive haemolytic anaemia, neutropenia, dissiminated intravascular coagulation, hypoprothrombinaemia, and thrombocytopenia (Belkin, 1976; Pfueller et al., 1988; Spearing et al., 1990; Hagley et al., 1992; Aster, 1993; Maguire et al., 1993). Haemolysis can result when quinine is administered to patients with G6PD deficiency.
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Lately, there have been reports of patients experiencing side effects as a result of using Quinine. On Monday, the Kumi Hospital Medical Superintendent John Opolot asked the government to prohibit the use of Quinine injections because they were crippling children. He said mal-administration of Quinine injections has inflicted a range of physical and mental disabilities on children.
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