LYCOS RETRIEVER
Prograf
built 635 days ago
Prograf is ... available as a sterile solution (tacrolimus injection) containing the equivalent of 5 mg anhydrous tacrolimus in 1 mL for administration by intravenous infusion only. Each mL contains polyoxyl 60 hydrogenated castor oil (HCO-60), 200 mg, and dehydrated alcohol, USP, 80.0% v/v. Prograf injection must be diluted with 0.9% Sodium Chloride Injection or 5% Dextrose Injection before use.
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Pregnancy: Adequate studies have not been conducted on the use of Prograf by pregnant women. However, the use of Prograf during pregnancy has been associated with high blood potassium levels and kidney problems in the newborn. Prograf should be used during pregnancy only if the potential benefits outweigh the potential risks.
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Prograf concentrate for infusion should be protected from light and stored below 25°C. Once an ampoule is opened, the contents should be used immediately. Following reconstitution in either 5% w/v glucose solution in polyethylene or glass containers or in 0.9% Sodium Chloride Injection in polyethylene containers, the resulting infusion mixture is stable for 24 hours.
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Prograf is available in one-half milligram capsules, 1 milligram capsules and 5 milligram capsules. The 0.5 mg capsules are light yellow and oblong with “0.5 mg” written on the capsule top. The 1 mg capsules are white and oblong, with “1 mg” written on the capsule top. The 5 milligram capsules are grayish/red, oblong, and have “5 mg” written on the capsule top.
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Conversely, Prograf has been shown to, or may inhibit the metabolism of the following: ciclosporin, cortisone, testosterone, pentobarbital, antipyrine, and steroid-based contraceptive agents. Particular care should therefore be exercised when deciding on contraceptive measures.
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Prograf may cause fetal abnormalities and malformations. For this reason it is recommended that you do not take Prograf if you are, or become, pregnant. You must use a reliable method of birth control before, during your treatment and for 6 weeks after stopping your treatment with Prograf.
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