LYCOS RETRIEVER 
Prograf
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Prograf is a prescription medicine used to help keep your body's immune system from rejecting your new kidney or liver. Like all anti-rejection medicines, Prograf slows down your immune system. This helps protect your new organ from being rejected. But it ... weakens your body's ability to fight infections. Common side effects of Prograf include changes in the amount of urine, high blood sugar, headache, tremor (shaking of the body), diarrhea, nausea, constipation, high blood pressure, and infection.
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Patients receiving Prograf injection should be under continuous observation for at least the first 30 minutes following the start of the infusion and at frequent intervals thereafter. If signs or symptoms of anaphylaxis occur, the infusion should be stopped. An aqueous solution of epinephrine should be available at the bedside as well as a source of oxygen.
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The side effect that may be found when using Prograf will always vary upon the user. All drugs have side effects that will range from small complications such as weight gain or weight loss to sleep deprivation. As the side effects with Prograf will range from individual to individual we recommend that if you suspect any danger or possible overdose that you contact and seek medical attention from your local emergency clinic or in less severe cases phone your physician. For the best information on current drug side effects it is always best to go online to a news forum for recent info and reviews of the possible side effects, warnings and dangers of Prograf. To decrease the risks involved with any drug it is always best to follow a healthy lifestyle, take the correct dosage at the proper time and always follow the instructions on communicated to you by the pharmacist or doctor about how to take Prograf. As with all prescription drugs the manufacturer is required to name the recommended dosage and possible side effects of the products that they have for sale.
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Experience with Prograf in pediatric kidney and heart transplant patients is limited. Successful liver transplants have been performed in pediatric patients (ages up to 16 years) using Prograf. Two randomized active-controlled trials of Prograf in primary liver transplantation included 56 pediatric patients. Thirty-one patients were randomized to Prograf-based and 25 to cyclosporine-based therapies. Additionally, a minimum of 122 pediatric patients were studied in an uncontrolled trial of tacrolimus in living related donor liver transplantation. Pediatric patients generally required higher doses of Prograf to maintain blood trough concentrations of tacrolimus similar to adult patients (see DOSAGE AND ADMINISTRATION).
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When considering co-administration of Prograf with other drugs the potential for exacerbation of toxic effects should be carefully considered. Care should be taken when using compounds known to have nephrotoxic effects, such as aminoglycosides, amphotericin B, co-trimozazole, gyrase inhibitors, NSAIDs and vancomycin. When Prograf is administered together with potentially neurotoxic substances such as ganciclovir or acyclovir, the neurotoxicity of these drugs may be enhanced. Tacrolimus has been shown to increase phenytoin blood levels. Hyperkalaemia has been reported in some patients receiving Prograf; where there is a risk of hyperkalaemia, potassium-sparing diuretics should be avoided. Care should ... be taken when administering potassium supplements or other agents known to increase serum potassium levels.
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Prograf has been approved for use as an immunosuppressive for the prevention of organ rejection in kidney transplant recipients. It is manufactured in capsule and injection form. Previously, Prograf has been used since 1994 for the prophylaxis of rejection in liver transplants.
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Prograf