LYCOS RETRIEVER 
Prograf: Drugs
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Prograf is extensively metabolised via the hepatic microsomal cytochrome P-450 enzyme system. In particular, Prograf has shown a broad and powerful inhibitory effect on cytochrome P-450 3A4. Prograf may have an inducing or inhibitory effect on these enzymes and care should be taken when co-administering other drugs known to be metabolised by the cytochrome P-450 enzyme system.
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Hypertension is a common adverse effect of Prograf therapy (see ADVERSE REACTIONS ). Mild or moderate hypertension is more frequently reported than severe hypertension. Antihypertensive therapy may be required; the control of blood pressure can be accomplished with any of the common antihypertensive agents. Since tacrolimus may cause hyperkalemia, potassium-sparing diuretics should be avoided. While calcium-channel blocking agents can be effective in treating Prograf-associated hypertension, care should be taken since interference with tacrolimus metabolism may require a dosage reduction (see Drug Interactions ).
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The drug is owned by Astellas Pharma Inc. (Merger of Fujisawa Pharmaceutical Co., Ltd. and Yamanouchi Pharmaceutical Co., Ltd. as of April 1, 2005) and is sold under the tradenames Prograf®, Advagraf, and Protopic®. It is sometimes referred to as FK-506, an early name relating to its action. It was first approved by the Food and Drug Administration (FDA) in 1994 for use in liver transplantation, this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, bone marrow, and limb transplants.
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You have received a prescription for Prograf capsules from your doctor. As you know, you need special education, every day, to help keep your transplanted organ healthy and functioning. Prograf is a drug that is used to help your body accept your transplanted organ.
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The number of tablets or capsules prescribed per-day depends on the strength of the prescription drug Generic for Prograf. In addition, the amount of tablets or capsules taken, the time between doses, and the duration the drug is taken is dependant on the medical problem related to the prescription and the discretion of the physician prescribing the drug. Always follow the instructions given to you by your physician.
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Your doctor will give you specific instructions about how much Prograf you should take each day. Your doctor has decided the dose you should take based on your medical condition and response to the drug.
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