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Prevnar
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Prevnar is a sterile solution of saccharides of the capsular antigen of S.pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F and 23F and diphtheria CRM197 protein. Individual polysaccharides are prepared from purification of the culture broth of each serotype. The saccharides are directly conjugated to the protein carrier CRM197 protein by reductive animation. CRM197 is a nontoxic variant of diphtheria toxin isolated from cultures of C. diphtheriae strain C7(B197) and/or C.diphtheriae strain C7 (B197) pPx350 grown in a casamino acids and yeast extract-based medium. CRM197 is purified through ultrafiltration, ammonium sulfate precipitation, and iron-exchange chromatography to high purity. Each serotype is conjugated as a monovalent preparation prior to compounding as a multivalent vaccine.
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Prevnar® is one of the vaccines in the recommended childhood immunization schedule. This vaccine protects against disease caused by bacteria called Streptococcus pneumoniae. This bacteria can cause serious illness, including meningitis (an infection of the covering of the brain), blood stream infections, and infection of the lungs. Streptococcus pneumoniae can infect anyone, but is most likely to cause serious infection in infants and in children with certain medical conditions. Infants and toddlers should usually get four doses of Prevnar®, one dose at 2 months, 4 months, 6 months, and 12-15 months of age.
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PNEUMOCOCCAL VACCINE, POLYVALENT (Pneumovax®, Prevnar™) helps to prevent infection caused by strains of pneumococcus bacteria. These bacteria are a major cause of ear infections, 'Strep throat' infections, and serious pneumonia, meningitis, or blood infections worldwide. These vaccines help the body to produce antibodies (protective substances) that help you fight these bacteria. The Prevnar™ pneumococcal vaccine is recommended for infants and young children. Pneumovax® is recommended for certain children and adults with increased risks for these infections. Different brands and types of pneumococcal vaccine are available.
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For infants, the immunization series of Prevnar® consists of 3 doses of 0.5 mL each, at approximately 2-month intervals, followed by a fourth dose of 0.5 mL at 12 to 15 months of age. The customary age for the first dose is 2 months of age, but it can be given as young as 6 weeks of age. The recommended dosing interval is 4 to 8 weeks. The fourth dose should be administered at least 2 months after the third dose.
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Approved in 48 countries, Prevnar has ... far been launched in 24 countries, including most European countries. Although granted a coveted spot in the paediatric immunisation schedule in the U.S, European governments have been less hasty to implement a recommendation for mass immunisation of infants. While most paediatric vaccines now cost between $6 and $20 per dose, Prevnar, costs a substantial $60. In Europe, the vaccine commands a similar premium price compared to the U.S. For example, in the UK, the price of one dose equates to approximately $56.
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Prevnar is given as a four dose series, starting at two months of age (with a minimum of six weeks of age). Subsequent doses are given at age four months and six months, with a fourth dose given between 12-15 months of age (and at least two months after the third dose). It is recommended that all children under the age of 23 months be given this vaccine.
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Prevnar