LYCOS RETRIEVER 
Phenytoin: Treatments
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Phenytoin (diphenylhydantoin or Dilantin) is a highly effective and widely prescribed anticonvulsant agent used in the treatment of grand mal and psychomotor epilepsy. In dermatology, phenytoin has been used to treat ulcers, epidermolysis bullosa, and inflammatory conditions. Its mechanism appears to involve its ability to inhibit collagenase. Its topical use for the promotion of wound healing seems promising but requires further trials. The side effects of phenytoin continue to create significant morbidity. Common side effects include gingival hyperplasia, coarsening of the facies, and hirsutism.
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Phenytoin is in the FDA pregnancy category C. This means that it is not known whether phenytoin will be harmful to an unborn baby. Do not take phenytoin without first talking to your doctor if you are pregnant or could become pregnant during treatment.
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Phenytoin has been used to treat neuropathic pain. It now appears... that gabapentin is preferred to treat such pain over other anticonvulsants. Carbamazepine and phenytoin were the first anticonvulsants to be used in controlled clinical trials and shown to relieve painful diabetic neuropathy and paroxysmal attacks in trigeminal neuralgia.[51] However, an evidence-based review of these trials found them unproven in affect.[52] Similarly, phenytoin was found ineffective in the treatment of diabetic symmetrical polyneuropathy.[53]
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