LYCOS RETRIEVER 
Phenytoin: Phenytoin Sodium
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The pathogenesis of RDEB is thought to be due to increased collagenase activity by the fibroblasts.[1] Phenytoin sodium has been demonstrated to inhibit collagenase activity in vitro,[1] ... helping to control the formation of bullae. However blood levels higher than 8 mg/litre are required.[4],[5]
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Phenytoin blocks voltage-sensitive sodium channels in neurons. This action leads to a delay in neuronal electrical recovery. Phenytoin’s inhibitory effect is dependent on the voltage and frequency of neural cell firing by selectively blocking the neurons that are firing at high frequency. Phenytoin prevents the electrical spread of a focus of irritable tissue from entering normal tissue.
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Phenytoin sodium has been marketed as Phenytek® by Mylan Laboratories, previously Bertek Pharmaceuticals, and Dilantin®; ... Dilantin® Kapseals® and Dilantin® Infatabs® in the USA, and as Epanutin® in the UK and Israel, by Parke-Davis, now part of Pfizer. In the USSR and post-USSR countries, it was/is marketed as Дифенин (Diphenin, Dipheninum).
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Phenytoin Sodium