LYCOS RETRIEVER 
Phenytoin: Drugs
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Phenytoin is a category D drug. Various congenital anomalies have been reported from usage during pregnancy (see Fetal hydantoin syndrome). No scientific data have demonstrated that effect or outcome of acute toxicity is based on sex.
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Phenytoin rarely induces other types of inflammatory and disorders of keratinization. Phenytoin has been linked to drug-induced linear IgA bullous dermatosis.[131] It may be linked to the development of sarcoidosis,[132] specifically pulmonary sarcoidosis.[133] Thickening of the heel pad associated with long-term phenytoin therapy has been reported.[134]
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The pseudolymphoma syndrome has been described as a hypersensitivity reaction to anticonvulsant drugs especially Phenytoin (Diphenylhydantoin). Its pathogenesis is unknown. It consists of a triad of fever, generalised rash and lymphadenopathy. In some cases, varying degrees of malaise, hepatosplenomegaly, abnormal liver function tests, arthralgia, eosinophilia and blood dyscrasias may be present. [1]
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