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Pertussis: Diphtheria
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2008 Yellow Book Cover - Right Nav Local reactions (erythema and induration with or without tenderness) are common after the administration of vaccines containing diphtheria, tetanus, and pertussis antigens. Mild systemic reactions such as drowsiness, fretfulness, and low-grade fever can occur after vaccination with DTaP. These reactions are self-limited and can be managed with symptomatic treatment of acetaminophen or ibuprofen. Swelling involving the entire thigh or upper arm has occurred after the fourth and fifth doses of DTaP. These reactions are ... self limited (1). Prelicensure studies support the safety of Tdap, with an overall safety profile of local and systemic events comparable with that of Td.
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Whenever feasible, the same brand of diphtheria, tetanus, and acellular pertussis vaccine should be used for all doses of the vaccination series. Data do not exist regarding the safety, immunogenicity, and efficacy of using diphtheria, tetanus, and acellular pertussis vaccines from different manufacturers for successive doses of the primary or booster vaccination series. However, the vaccine provider may not know or may not have available the type of diphtheria, tetanus, and acellular pertussis vaccine previously administered to a child. Neither circumstance should present a barrier to administration of the vaccine and any of the licensed diphtheria, tetanus, and acellular pertussis vaccines may be used to complete the vaccination series.
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The DPT vaccine is given to children to prevent diphtheria, pertussis (whooping cough) and tetanus. The pertussis portion of the DPT shot is composed of killed B. pertussis bacteria, the same bacteria that cause whooping cough. In the bacteria are toxins which are responsible for the neurological complications of both the vaccine and the disease. The DTaP vaccine contains a purified acellular version of the pertussis vaccine and has fewer B. pertussis toxins in it. The DTaP vaccine is associated with fewer reactions but can still cause injuries and death.
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While there is no lifelong protection against pertussis, vaccination is the best way for you to protect your child. The vaccine used to protect children from pertussis is the diphtheria, tetanus, and acellular pertussis (DTaP) vaccine. This vaccine ... protects children from 2 other serious diseases caused by bacteria: diphtheria and tetanus. Most children who are vaccinated with the DTaP vaccine will be protected from all 3 diseases throughout childhood.
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MBPI makes the pertussis vaccine, rabies vaccine and diphtheria, pertussis, tetanus vaccine components, as well as plasma derivatives of albumin and immune globulin. In fact, according to some reports, MBPI is the only source of immune globulin. According to the PRNewswire report announcing the $29 million dollar award to BioPort Corp. for anthrax vaccine production, BioPort expects to earn most of its revenue from the sale of the anthrax vaccines to DoD and from its plasma fractionation services.
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Vaccination (vak-sih-NAY-shun) is the best way to prevent pertussis in children. The vaccine for pertussis is given in a combined vaccine including those for diphtheria* and tetanus*. The DTaP vaccine (made with acellular pertussis, which contains only parts of the pertussis bacterium and does not cause as many side effects as the vaccine made with the whole bacterium) is given in multiple doses, starting at 2 months of age.
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