LYCOS RETRIEVER
Pain Relief: Patients
built 634 days ago
AZ-001 met the primary efficacy endpoint of the clinical trial, which was pain relief at 2-hours post-dose using the IHS 4-point scale, for all three doses of the drug compared to placebo. Statistically significant improvements in pain response were observed in 66.0% of patients at the 10 mg dose (p=0.0013), 63.7% of patients at the 7.5 mg dose (p=0.0046) and 60.2% of patients at the 5 mg dose (p=0.0076), compared to 40.8% of patients receiving placebo.
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FLECTOR(R) Patch delivers significant pain relief with no serious adverse events observed in clinical trials for up to two weeks with approximately 600 patients. In addition, the incidence of gastrointestinal side effects such as nausea and upset stomach were comparable to placebo patch.
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One of the most important clinical benefits associated with long-acting opioids is that—by virtue of their prolonged pain relief—they eliminate the need to take a pill every three to four hours. Taking a pill this often conditions a "sickness" behavior in patients. Instead of becoming independent, patients may become dependent on pill taking.
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