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Nortriptyline: Tricyclic Antidepressants
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Nortriptyline, a tricyclic antidepressant, is a derivative and metabolite of amitriptyline and is used to treat endogenous depression. The half-life of nortriptyline is 20-80 hours. Nortriptyline may be associated with cholestasis and cholestatic jaundice. Hematological consequences include agranulocytosis, purpura, and thrombocytopenia. Other side effects include a host of GI, endocrinologic, allergic, anticholinergic, cardiovascular, and neurologic disorders.
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Nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline. Nortriptyline is similar to protriptyline. Nortriptyline is used to treat depression and for the management of chronic, severe neurogenic pain. Some efficacy has been reported with nortriptyline in social anxiety disorder and panic disorder.
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Nortriptyline shares side effects common to all tricyclic antidepressants. The most frequent of these are dry mouth, constipation, urinary retention, increased heart rate, sedation, irritability, dizziness, and decreased coordination. As with most side effects associated with tricyclic antidepressants, the intensity is highest at the beginning of therapy and tends to decrease with continued use.
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Nortriptyline may be less likely than other tricyclic agents to produce orthostatic hypotension, particularly in the elderly. It ... may be relatively safer than other tricyclic antidepressants in cardiac patients, including those who have received a transplant.
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Nortriptyline is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA), and is the active metabolite of amitriptyline. The mechanism of action of TCAs believed to be related to their inhibition of the presynaptic reuptake of neurotransmitters, including serotonin and norepinephrine, which potentiates the effects of the neurotransmitters. As with other antidepressants, several weeks of therapy may be required in order to realize the full antidepressant effect of nortriptyline.
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Nortriptyline is a tricyclic antidepressant used to relief depression. The exact mechanism of Nortriptyline action is unknown. Probably, it restores the balance of certain natural substances in the brain (serotonin and norepinephrine).
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Tricyclic Antidepressants