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Nortriptyline: Drugs
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Nortriptyline is used to relieve symptoms of depression. The drug is more effective for endogenous depression than for other forms of depression. Endogenous depression is depression arising from metabolic changes within a person, such as chemical or hormonal imbalances. Nortriptyline is ... used occasionally to treat premenstrual depression, attention-deficit/hyperactivity disorder in children, and bed-wetting (enuresis).
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Keep Nortriptyline in the container it came in, tightly closed and away from light. Be sure to keep this drug out of reach of children; an overdose is particularly dangerous in the young. Store at room temperature.
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Nortriptyline is distributed into the lungs, heart, brain, and liver. Nortriptyline is known to cross the placenta and is ... distributed into breast milk. Plasma half-life of nortriptyline is between 16 and 90 hours. Metabolism takes place in the liver. Nortriptyline is lipophilic, facilitating crossing of the blood-brain barrier. There may be enterohepatic circulation and secretion of both unchanged drug and metabolites into gastric juice.
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Nortriptyline may increase the possibility of having seizures. Patients should tell their physician if they have a history of seizures, including seizures brought on by the abuse of drugs or alcohol. These people should use nortriptyline only with caution and be closely monitored by their physician. Nortriptyline can ... cause ringing in the ears, tingling in the extremities, and numbness in the extremities, although none of these side effects are common when the drug is used as directed.
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Be aware that Nortriptyline may interact with some medicines. Consult with your health care provider in case you are taking any other drugs, especially any of the following: azole antifungals (eg, fluconazole), cimetidine, duloxetine, flecainide, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or terbinafine because the side effects of Nortriptyline may be increased; arsenic, astemizole, cisapride, dofetilide, droperidol, furazolidone, MAO inhibitors (eg, phenelzine), pimozide, quinolone antibiotics (eg, ciprofloxacin), streptogramins (eg, dalfopristin), terfenadine, tramadol, or ziprasidone because the risk of high blood pressure, serious heart problems (eg, irregular heartbeat), or seizures may be increased; barbiturates (eg, phenobarbital) or phenytoin because the effectiveness of Nortriptyline may be decreased; anticholinergics (eg, benztropine), carbamazepine, chlorpropamide, or sympathomimetics (eg, phenylephrine) because side effects may be increased by Nortriptyline; clonidine, guanethidine, or guanfacine because effectiveness may be decreased by Nortriptyline.
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