LYCOS RETRIEVER 
Nolvadex: Breast Cancer
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Researchers from Italy recently conducted a clinical trial to determine if Nolvadex ® may reduce the risk of breast cancer in women at high-risk for developing the disease. The trial involved approximately 5,000 women who received either Nolvadex ® or placebo (inactive substitute) between 1992 and 1997. Upon initiation of this trial, women did not have breast cancer and had previously undergone a hysterectomy. Half of the women in this trial had ... previously had their ovaries removed.
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Although Nolvadex reduces the risk of breast cancer, it increases the possibility of developing endometrial (uterine) cancer. Women taking Nolvadex should have routine gynecological examinations and report any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure to the doctor immediately. Even after Nolvadex therapy has stopped, any abnormal vaginal bleeding should be reported at once.
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Nolvadex uses: Used to treat breast cancer. Tamoxifen ... is used to treat mastalgia and for decreasing the size and pain of gynecomastia (swelling and tenderness of the breast). Tamoxifen also may be useful in pancreatic, endometrial, and hepatocellular cancer.
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These researchers concluded that women at a high-risk for developing hormone-dependent breast cancer may benefit from preventive therapy with Nolvadex ®. However, it is important for these women to discuss their risk for developing breast cancer as well as all the risks and benefits of receiving Nolvadex ® with their physician. Future clinical trials are warranted to determine the true clinical effectiveness of preventive Nolvadex ® in women at a high risk for developing hormone-dependent breast cancer. Patients with high-risk characteristics may wish to discuss the risks and benefits of Nolvadex ® or participation in a clinical trial evaluating preventive strategies for breast cancer with their physician. Two sources of information regarding ongoing clinical trials include the National Cancer Institute ( cancer.gov) and www.eCancerTrials.com. ECancerTrials.com ... provides personalized clinical trial searches on behalf of patients.
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While practically similar compounds in structure, few people ever really consider Clomid and Nolvadex to be similar. Its not just a common myth in steroid circles, but even in the medical community. This misconception originates from their completely different uses. Nolvadex is most commonly used for the treatment of breast cancer in women, while clomid is generally considered a fertility aid. In bodybuilding circles, from day one, clomid has generally been used as post-cycle therapy and Nolvadex as an anti-estrogen.
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Overall, 34 women who had received Nolvadex ® developed breast cancer, compared to 45 women who had received placebo. However, in the group of patients with high-risk characteristics including early age at onset of menstruation, no pregnancies, late age at first pregnancies or a high body mass index were 82% less likely to develop hormone-dependent breast cancer if they had received Nolvadex ®, compared to placebo.
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