LYCOS RETRIEVER 
Niaspan: Flushing
built 675 days ago
Figure 1 Dose-related efficacy of Niaspan: data from three pivotal clinical studies involving 245 Niaspan-treated patients.2–5 HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides. Adapted from Sprecher DL [E]t al. Raising high-density lipoprotein cholesterol with niacin and fibrates: a comparative review. Am J Cardiol 2000;86:46L–50L. © 2000, with permission from Excerpta Medica Inc.
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"The Niaspan/simvastatin combination tablet is a promising next step in our efforts to develop therapies that support more comprehensive cholesterol management with one pill," said Eugene Sun, M.D., vice president of Global Clinical Development, Abbott. "Combination lipid therapies are an increasing trend to help physicians reach their patients' treatment goals."
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Treatment with four different doses of Niaspan combined with simvastatin for 24 weeks was well tolerated. There was no evidence for increased risk of hepatotoxicity or myopathy with the combination. Six percent of patients on Simcor therapy discontinued due to flushing compared to 0.8 percent with simvastatin alone.
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Niaspan is the only FDA-approved, once-daily extended-release prescription niacin formulation for the treatment of lipid disorders with an ability to significantly raise HDL cholesterol. Collective results from three major clinical studies show an average 22 percent increase of HDL for patients receiving 2000 mg of Niaspan at bedtime. Niacin is ... indicated for the secondary prevention of heart attacks, and in combination with a bile acid binding resin, niacin is indicated to promote regression of coronary atherosclerosis in patients with history of coronary artery disease.
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Niaspan... known as niacin, is vitamin B3. It occurs naturally in plants and animals, and it is also added to many foods in small amounts as a vitamin supplement. Niaspan is also present in small amounts in many multiple vitamins and nutritional supplements.
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Niaspan Controlled-Release Tablets may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Niaspan Controlled-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
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