LYCOS RETRIEVER 
Niaspan: Effects
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Niaspan can cause certain side effects, such as flushing (warmth, itching, redness, or tingly feeling under your skin). These effects can be made worse if you drink alcohol or hot beverages shortly after you take Niaspan. These effects should disappear over time as you keep taking the medication.
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Lipoprotein(a) levels were significantly reduced by 20% from baseline with 2000 mg of Niaspan (P=.002) (Figure 5). Lipoprotein(a) trended higher with gemfibrozil, but the effect was not statistically significant. Effects on fibrinogen level, another atherosclerotic risk factor, were small, but gemfibrozil significantly increased the fibrinogen level by 6% to 9% (P=.04), while Niaspan gave a nonsignificant trend toward lower fibrinogen levels (Figure 5). Niaspan, 2000 mg, had a significantly better effect on fibrinogen levels than gemfibrozil.
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The primary purpose of this study is to test the effectiveness and tolerability of Niaspan® to improve the levels of blood fats (“good” and “bad” cholesterol and triglyceride levels) in people who have kidney damage due to diabetes. A secondary goal is to test whether Niaspan® slows down further development of kidney damage.
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Although it is sometimes stated that Niaspan can be combined with other cholesterol-lowering medications (Zocor, Lipitor, Lescol, etc.), such mixture has proved to cause muscle damage... it should be avoided. Correspondingly, the use of niacin and bile acid sequestrants for cholesterol lowering must be done 4 to 6 hours apart not to erase Niaspan effect on the body.
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Three multi-centre, double-blind, placebo-controlled studies have addressed the effects of Niaspan, given as monotherapy, in patients with primary hyperlipoproteinaemia despite treatment with diet. One study evaluated the effects of Niaspan at doses between 500 and 3000 mg, with the dose increased by 500 mg at 4-week intervals.2 The second study evaluated Niaspan at doses of 1000 and 2000 mg over 12 weeks of treatment,3 whereas the third was a 16 week study designed to compare the effects of Niaspan 1500 mg on lipids with various doses of immediate-release nicotinic acid.4
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