LYCOS RETRIEVER 
Niacin: Niacin Flush
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Niacin lowers LDL-cholesterol (LDL-C) and triglycerides (TGs) and increases HDL-cholesterol (HDL-C). It causes a shift from small, dense to large, buoyant LDL particles that are less atherogenic. Niacin ... significantly lowers lipoprotein A levels. Immediate-release niacin may cause itching, flushing, headache and requires frequent daily dosing. Adverse effects may be attenuated by increasing the dose slowly and/or by taking aspirin 30-60 minutes before dosing. Compliance is enhanced with twice daily dosing.
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Niacin comes in a variety of different forms, ranging from fast-acting forms to those that are longer acting. Some forms of niacin, especially in high doses — 1,000 milligrams or more — do cause temporary flushing of the skin. While annoying, this flushing is not harmful. Also, talk to your doctor about taking an aspirin shortly before you take your niacin. Aspirin can counteract this flushing effect. Versions of niacin with reduced flushing effects ... are available by prescription.
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Niacin is safe -- except in people with chronic liver disease or certain other conditions, including diabetes and peptic ulcer. It is ... inexpensive. Unfortunately, it has numerous side effects. It can cause rashes and aggravate gout, diabetes, or peptic ulcers. Early in therapy, it can cause facial flushing for several minutes soon after a dose, although this response often stops after about two weeks of therapy and can be avoided by taking an aspirin or ibuprofen half an hour before taking the niacin. A sustained-release preparation of niacin (Niaspan) may have fewer side effects, but can cause severe liver damage, especially when combined with a statin.
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Niacin (not niacinamide) produces dilation of the blood vessels in the skin, particularly in the upper body. As a result, a dose of 100 mg taken on an empty stomach may produce flushing of the skin with intense itching or burning. A sustained-release form does not prevent the flushing, only delays it. Niacinamide does not produce this effect. Niacinamide does not affect the cardiovascular system or alter lipid levels.
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Niacin is involved in the proper metabolism of fat and fat-like substances such as cholesterol. Niacin taken in a single 500mg often causes flushing or itching. Niacin-time contains niacin prepared by a patented method to minimize these unpleasant side effects. With many people there is absolutely no flush, and the amount needed is sometimes less than needed with other forms of Niacin. Each niacin-time tablet provides a gradual release of 500mg over a period of 5 to 7 hours for sustained absorption.
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