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Niacin: Flushing
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Niacin is available over-the-counter and with a prescription under many different brand names. Generic forms are ... be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
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Niacin at extremely high doses can have life-threatening acute toxic reactions. One patient suffered vomiting after taking eleven 500-milligram niacin tablets over 36 hours, and another was unresponsive for several minutes after taking five 500-milligram tablets over two days.[21][22] Extremely high doses of niacin can ... cause niacin maculopathy, a thickening of the macula and retina which leads to blurred vision and blindness.[23]
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Niacin 250 mg, vegetarian, dietary supplement.Niacin provides nutritive support for the normal, healthy metabolism of carbohydrate, protein, and fat for energy as well as maintaining the integrity of the skin, nerves and digestive tract. Contians No Addded: Yeast, Wheat, Corn, Milk, Egg, Soy, Glutens, Animal Derivatives, Sugar, Artificial Colors or Preservatives.
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Niacin increased HDL levels over 25%, compared to an increase of 13.3% due to gemfibrozil. Gemfibrozil actually raised LDL (the “bad” cholesterol, remember?), while niacin slightly lowered this fraction. Gemfibrozil lowered triglyceride levels by 40%, compared to a 30% decrease from niacin. Thus, niacin resulted in an overall improvement in the lipid profile which exceeded that induced by gemfibrozil (Fig. 1).
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Heart disease: Niacin is used in therapeutic doses to treat various forms of hyperlipidemia. Niacin has been shown to be effective in lowering plasma triacylglycerol and LDL concentrations, while raising plasma HDL concentrations. Mechanism of action by niacin differs from lipid-lowering medications, giving the rationale for combination therapy for complete lipid goal achievement. 6
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Niacin has been important to the field of orthomolecular nutrition for its use supporting the higher functions of the brain and cognition. While niacin was originally helpful for the dementia of pellagra, high doses have been used to support normal mood and psychological function. This continues to be a controversy, though there are some studies that showed promising results.
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