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Naproxen: Drugs
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Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid chemical class. Naproxen possesses antipyretic and analgesic properties. Naproxen is chemically related to ibuprofen, ketoprofen, flurbiprofen, and fenoprofen. Naproxen tablets were approved by the FDA in 1976. On January 11, 1994, the FDA approved naproxen in a nonprescription form (e.g., Aleve).
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Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. Naproxen ... helps relieve symptoms of ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. However, this medicine does not cure arthritis and will help you only as long as you continue to take it .
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Naproxen delayed-release tablets are designed with a pH-sensitive coating to provide a barrier to disintegration in the acidic environment of the stomach and to lose integrity in the more neutral environment of the small intestine. The enteric polymer coating selected for Naproxen delayed-release tablets dissolves above pH 6. When Naproxen delayed-release tablets were given to fasted subjects, peak plasma levels were attained about 4 to 6 hours following the first dose (range: 2 to 12 hours). An in vivo study in man using radiolabeled Naproxen delayed-release tablets demonstrated that Naproxen delayed-release tablets dissolve primarily in the small intestine rather than in the stomach, so the absorption of the drug is delayed until the stomach is emptied.
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DRUG CLASS AND MECHANISM: Naproxen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase ), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.
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During long-term administration, the dose of Naproxen may be adjusted up or down depending on the clinical response of the patient. A lower daily dose may suffice for long-term administration. The morning and evening doses do not have to be equal in size and the administration of the drug more frequently than twice daily is not necessary.
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Health Canada is proposing to let a form of Naproxen be sold without a prescription for the first time, which would make the popular drug easily the most powerful painkiller available over the counter. via Canada.com
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