LYCOS RETRIEVER 
Metronidazole: Treatment
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Metronidazole may increase the effect of warfarin (used to prevent blood clotting) and some antimicrobial agents, such as clindamycin, erythromycin, rifampicin and nalidixic acid. Phenobarbitone (used for epilepsy) reduces the effect of metronidazole. Cimetidine (used in the treatment of gastric ulcer) may intensify the effect of metronidazole.
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Metronidazole may enhance the anti-blood-clotting effect of anticoagulant medicines such as warfarin and nicoumalone, and this may increase the risk of bleeding. If you are taking an anticoagulant medicine your blood clotting time (INR) should be monitored during treatment with a course of metronidazole, and your doctor may need to reduce your anticoagulant dose.
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Metronidazole is listed by the International Agency for Research on Cancer (IARC) as a potential human carcinogen. Although some of the testing methods have been questioned, it has been shown to cause cancer in experimental animals.[4] Nevertheless, it appears to have a fairly low potential for cancer risk and under most circumstances the benefits of treatment outweigh the risk.
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