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Mesothelioma Clinical Trial: Studies
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This is a Phase II clinical trial to evaluate the use of Alimta (pemetrexed disodium) and either Gemcitabine or Carboplantin in treating mesothelioma patients. Both Alimta and Gemcitabine are antimetabolic agents that block cancer cell growth by not allowing the metabolism process in the cell DNA. Carboplantin is a platinum compound that directly damages cancer cell DNA through alkylation. This study will determine if the different types of drugs work better in combination to slow or stop the progression of mesothelioma.
Mesothelioma clinical trials follow a plan of very strict scientific guidelines, which is called a protocol. The protocol explains everything that will happen in the study. It must be approved by review boards made up of health care professionals and other qualified people before the study can enroll patients.
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Enrollment in any clinical trial is completely up to you. Your doctors and nurses will explain the study to you in detail and will give you a form to read and sign indicating your desire to take part. This process is known as giving your informed consent. Even after signing the form and after the clinical trial begins, you are free to leave the study at any time, for any reason. Taking part in the study does not prevent you from getting other medical care you may need.
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One of the most important points in deciding if a clinical trial can be done is whether or not it would be ethical to ask patients, many of whom are in desperate situations, to volunteer for an experimental treatment. Has the study been designed, as much as possible, to ensure the safety of the people involved? Would the participants receive a treatment that is at least as good as, and possibly better than, what they would get if they did not volunteer for the study? A scientific review panel and an institutional review board of the participating institution review and approve all clinical trials to make sure questions like these are answered before the researchers are allowed to enroll patients.
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If you research on your own, you should know that the number of clinical trials for tests and treatments for mesothelioma has increased dramatically in the last few years. Following are just some of the clinical trials (all are Phase II unless otherwise specified) currently underway for studying mesothelioma treatments. This list-which does not include every available trial-is grouped generally by the type of treatment being tested so that you can sort through it a little more easily. The categories are:
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