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Melatonin: Melatonin Supplements
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Melatonin supplementation should be avoided in women who are pregnant or attempting to become pregnant, based on possible hormonal effects. High levels of melatonin during pregnancy may increase the risk of developmental disorders. In animal studies, melatonin is detected in breast milk and therefore should be avoided during breastfeeding. In men, decreased sperm motility and decreased sperm count are reported with use of melatonin.
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Melatonin supplements have been clinically shown to be an effective treatment for jet lag, sleep disorders and moodiness. Melatonin appears to be involved in the natural biorhythm of the body, that is known as the "circadian" rhythm. This refers to the internally built clock that signals the secretion of various nutrients at different times to regulate all body functions. Melatonin plays a key role as the biological timekeeper. It ... seems to function in controlling periods of sleepiness and wakefulness.
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Melatonin is a substance naturally produced by your body's pineal gland. It is a synthesis of two compounds, tryptophan (an amino acid) and serotonin (a neurotransmitter) and is central to your body's preparedness for sleep. Thus, melatonin is another powerful influence on your body clock and the recommendations for the use of melatonin supplements in your
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Melatonin ... regulates immunity. One group of doctors reported two successfully treated cases of sarcoidosis that it attributed to melatonin’s immune-modulating effect.12 Also, because of its effects on the immune system, melatonin has been given to people with cancer in many research trials. Low blood levels of melatonin are associated with an increased risk of uterine cancer.13 Melatonin has significantly reduced the level of prostate specific antigen (PSA, a marker for cancer) in prostate cancer patients.14 Melatonin inhibits breast cancer cells in test tubes15 and has put some women with breast cancer into remission in preliminary research.16 Melatonin supplementation has improved disease-free survival in people with melanoma17 and increased survival in people with brain cancer18 and lung cancer.19 Melatonin exerts anti-inflammatory activity that may be responsible for its anticancer properties.20
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Melatonin dietary supplements are available without a prescription from health food stores, drugstores, and mail-order catalogs and on the Internet. Melatonin should only be taken in its synthetic (man-made) form. The biological form, made from ground-up cow pineal glands, is rarely used because it may transmit disease.
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Melatonin: A hormone produced by the pineal gland, melatonin is intimately involved in regulating the sleeping and waking cycles, among other processes. Melatonin supplements are sometimes used by people who have chronic insomnia. Always see your doctor before taking melatonin, as it is not recommended for all patients with sleep problems.
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Melatonin Supplements