LYCOS RETRIEVER 
Melatonin: Effects
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Melatonin is one of the least toxic substances known. In one extensive clinical trial, a high dose of 75 milligrams of melatonin per day was given to 1400 women in the Netherlands for up to four years with no ill effects.
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Melatonin causes almost immediate drowsiness, and should not be consumed with depressants or alcohol. Melatonin is generally thought to be safe when used on occasion; but the long-term effects of melatonin usage are unknown.
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Melatonin has been found to be helpful when used with dogs who have "thunder-phobia," other noise-related reactions and other stressful situations. Melatonin has been used effectively to reduce seizures in dogs that seize between 11:00 PM and 6:00 AM. Quite a few members of our Canine Epilepsy community have ... discovered that it seems to lessen the frequency and/or severity of seizures at other times of the day.
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