LYCOS RETRIEVER 
Magnesium: Muscles
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Magnesium has a calming effect on the nervous system. With this, it is frequently used to promote good sleep. But more importantly it can be used to calm irritated and over-excited nerves. This is especially useful with epileptic seizures, convulsions in pregnant women and the `shakes' in alcoholism. Magnesium levels are generally low in alcoholics, contributing or causing many of their health problems. If magnesium levels are low, the nerves lose control over muscle activity, respiration and mental processes.
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Magnesium and potassium ... have a close relationship. Magnesium is necessary for the function of the sodium/potassium pump. If a magnesium deficiency occurs, then pumping sodium out of the cell and pumping potassium into the cell may be impaired (5). Prescription diuretics tend to deplete magnesium and potassium. In this situation, magnesium intake can normalize both magnesium and potassium levels in the muscle (5).
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Magnesium interferes with the absorption of digoxin (a heart medication), nitrofurantoin (an antibiotic), and certain anti-malarial drugs, which could potentially reduce drug efficacy. Bisphosphonates (e.g., alendronate and etidronate), which are drugs used to treat osteoporosis, and magnesium should be taken two hours apart so that the absorption of the bisphosphonate is not inhibited. Magnesium has ... been found to reduce the efficacy of chlorpromazine (a tranquilizer), penicillamine, oral anticoagulants, and the quinolone and tetracycline classes of antibiotics. Because intravenous magnesium has increased the effects of certain muscle relaxing medications used during anesthesia, it is advisable to let medical staff know if you are taking oral magnesium supplements, laxatives, or antacids prior to surgical procedures. High doses of furosemide (lasix) and some thiazide diuretics (e.g., hydrochlorothiazide), if taken for extended periods, may result in magnesium depletion (54, 55). Many other medications may also result in renal magnesium loss (3).
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