LYCOS RETRIEVER 
Liver: Damages
built 606 days ago
CTS-1027 significantly reduced liver damage following oral administration in four different preclinical models of liver injury. CTS-1027 markedly reduced aminotransferase (ALT) activity and improved survival and liver histology in the TNFalpha/Gln model. CTS-1027 was equally effective dosed at the same time as the insult or post-insult in the LPS/Gln model. CTS-1027 significantly reduced ALT activity in the Fas and Con A models. Dosing was well below or equivalent to exposure levels previously tolerated in human clinical studies.
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Now that you know how much your liver does for you, you're probably wondering what you can do for it. It's easy, really. Staying healthy is the best way to care for your liver. The liver can be damaged if a person is very overweight or drinks too much alcohol. So be active, eat right, and your liver will keep on loving you back!
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This has led to the use of the Couinaud classification of liver anatomy [Couinaud] which divides the liver into eight independent segments each with its own vascular inflow, outflow, and biliary drainage. Resections along these planes diminishes the chances of leaving non-viable tissue or damaging viable tissue. [Gazelle].
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