LYCOS RETRIEVER 
Lamivudine
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Lamivudine is available in tablets of 150 and 300 milligrams (mg). It is ... available in liquid form, manufactured both by GlaxoSmithKline and by Aurobindo Pharma. The normal dose of lamivudine is 300 mg daily: either one 300 mg tablet daily, or one 150 mg tablet twice a day. The dosage should be reduced for people who weigh less than 50 kilograms (110 pounds).
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Lamivudine, a synthetic antiretroviral agent, is a dideoxynucleoside reverse transcriptase inhibitor. Lamivudine is the negative enantiomer of a dideoxy analogue of cytidine and is structurally similar to zalcitabine (2',3'-dideoxycytidine, ddC). Lamivudine differs structurally from zalcitabine in that the 3'-carbon of the ribose ring is replaced with sulfur, forming an oxathiolane ring. The absence of a free 3'-hydroxy group on the oxathiolane ring results in the inability of lamivudine to form phosphodiester linkages at this position. Both the positive and negative enantiomers of 2',3'-dideoxy,3'-thiacytidine exhibit antiviral activity in vitro, but lamivudine appears to exhibit greater antiviral activity and to be considerably less cytotoxic than the positive enantiomer.[1]
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Lamivudine will not cure HIV or hepatitis B infection and you can still get other illnesses or complications associated with your disease. Taking lamivudine does not reduce the risk of passing HIV or hepatitis B infection to others through sexual or blood contact. It is best to avoid sexual contact so that you do not spread the disease to others. For any sexual contact, use a condom. Be careful about cuts, abrasions and other possible sources of blood contact. Never share a needle or syringe with anyone.
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Lamivudine is rapidly absorbed, with bioavailability from 80% to 88% in adults and adolescents and from 66% to 68% in children. Food delays the peak serum concentration; ... there is no significant difference in bioavailability when lamivudine is taken with food. Time to peak concentration (Tmax) is approximately 0.5 to 2 hours after a single 100 mg dose; with food, it increases to approximately 3.2 hours; with fasting, Tmax is about 1 hour.[17]
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Lamivudine has not been shown to reduce the risk of passing hepatitis B to other people through sexual contact or blood contamination. Use barrier forms of contraception (eg, condoms) if you are infected with hepatitis B virus.
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Lamivudine is ... available in Combivir, Trizivir and Epzicom. Combivir contains AZT and lamivudine. Trizivir contains AZT, lamivudine, and abacavir. Epzicom includes abacavir and lamivudine. For more information, see Fact Sheet 417 on Combivir, Fact Sheet 418 on Trizivir or Fact Sheet 422 on Epzicom.
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Lamivudine